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Project Z02: Modelling individual differences in response to stress in mice: an approach to identify neurobiological mechanisms underlying resilience

Principal Investigators

Prof. Dr. Marianne Müller

Professor

Konstantin Radyushkin, Ph.D.

Head of Mouse Behavior Outcome Unit

Prof. Dr. Beat Lutz

Professor and Director of the Institute of Physiological Chemistry

Project Team

Sarah Ayash, PhD student
Dr. Marija Milic, Postdoc
Dr. Michael van der Kooij, Postdoc
Niklas Schmitz, Animal caretaker

Our Research

The overarching aim of this central project is to set the animal experimental basis of this CRC in order to promote the understanding of neurobiological mechanisms underlying resilience to stress-related mental dysfunctions at the molecular-cellular, neural-network and behavioral levels. Specifically, this central project serves two major purposes: First, Z02 will be established as a state-of-the art service facility for other projects of this CRC initiative using the mouse as a model system. Second, Z02 will address genuine scientific questions, which will substantially contribute to our knowledge on appropriate mouse models for resilience research.

Publications

Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Van Diest I, van Harmelen A-L, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017) The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1:784-90.

>> Link to PubMed