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Project Z02: Modelling individual differences in response to stress in mice: an approach to identify neurobiological mechanisms underlying resilience

Principal Investigators

Prof. Dr. Marianne Müller

Professor

Group Leader at LIR

Prof. Dr. Beat Lutz

Professor and Director of the Institute of Physiological Chemistry

Scientific Director and Group Leader at LIR

Konstantin Radyushkin, Ph.D.

Head of Mouse Behavior Outcome Unit

Project Team

Our Research

The overarching aim of this central project is to set the animal experimental basis of this CRC in order to promote the understanding of neurobiological mechanisms underlying resilience to stress-related mental dysfunctions at the molecular-cellular, neural-network and behavioral levels. Specifically, this central project serves two major purposes: First, Z02 will be established as a state-of-the art service facility for other projects of this CRC initiative using the mouse as a model system. Second, Z02 will address genuine scientific questions, which will substantially contribute to our knowledge on appropriate mouse models for resilience research.

Publications

Ayash S, Schmidt U, Müller MB (2019) Chronic social defeat-induced social avoidance as a proxy of stress resilience in mice involves conditioned learning. J Psychiatr Res 120:64–71.

>> Link to PubMed

Zimmermann T, Bartsch JC, Beer A, Lomazzo E, Guggenhuber S, Lange MD, Bindila L, Pape HC, Lutz B (2019) Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses. Neuropsychopharmacology 44(8):1377–1388 doi: 10.1038/s41386-018-0274-7.

>> Link to PubMed

Jene T, Gassen NC, Opitz V, Endres K, Müller MB*, van der Kooij MA* (2018) Temporal profiling of an acute stressinduced behavioral phenotype in mice and the role of hippocampal DRR1. Psychoneuroendocrinology 91:149–158. *equal contribution

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van der Kooij MA*, Jene T*, Treccani G, Miederer I, Hasch A, Voelxen N, Walenta S, Müller MB (2018) Chronic social stress-induced hyperglycemia in mice couples individual stress susceptibility to impaired spatial memory. Proc Natl Acad Sci USA 115(43):E10187–E10196. *equal contribution

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Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Van Diest I, van Harmelen A-L, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017) The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1:784-90.

>> Link to PubMed