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Project C01: Making extinction last: role of spontaneous activity in a mesoprefrontal circuitry in long-term extinction memory consolidation

Principal Investigators

Prof. Dr. Albrecht Stroh

Junior Professor

Prof. Dr. Raffael Kalisch

Professor and Director of Neuroimaging Center Mainz (NIC)

Project Team

Dr. Felipe Aedo Jury, Postdoc
Elena Andres, PhD student
Consuelo Fois, PhD student
Anna Gerlicher, PhD student
Dr. Chuang Peng Hu, Postdoc
Dr. Benjamin Meyer, Postdoc
Dr. Anita Schick, Scientist
Dr. Kenneth S. L. Yuen, Postdoc

Our Research

The project investigates the role of spontaneous activity in the vmPFC and in its mesocortical dopaminergic inputs in the consolidation of fear extinction memories. Resting-state fMRI is used both in rodents and in humans. Physiological insights obtained from combining fMRI with Calcium recordings and optogenetics in rodents will deepen our understanding of neurobiological mechanisms in humans; advanced multivoxel analysis methods in humans, in turn, will guide and inform the analysis of fMRI and Calcium recording data in the rodent.

Publications

Haaker J, Lonsdorf TB, Schümann D, Bunzeck N, Peters J, Sommer T, Kalisch R (2017) Where There is Smoke There is Fear-Impaired Contextual Inhibition of Conditioned Fear in Smokers. Neuropsychopharmacology 42(8):1640-1646.

>> Link to PubMed

Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Van Diest I, van Harmelen A-L, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017) The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1:784-90.

>> Link to PubMed