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Project B05: Regulation of neural excitability and neural-network function in resilience – a multimodal and (back-) translational approach

Principal Investigators

Prof. Dr. Sergiu Groppa

Professor, Chair of Section of Movement Disorders and Neurostimulation, Consultant of the Clinic of Neurology

Prof. Dr. Albrecht Stroh

Junior Professor

PD Dr. Johannes Vogt

Principal Investigator

Project Team

Hendrik Backhaus, PhD student
Venkata Chaitanya Chirumamilla, PhD student
Dr. Gabriel Gonzalez Escamilla, Postdoc

Our Research

Using neuronavigated transcranial magnetic stimulation over human dorsomedial prefrontal cortex (as a probe) in combination with simultaneous EEG (as a read-out), B05 will determine the excitability and cortico-cortical functional connectivity of this cortex area, pursuing the hypothesis that adaptive stress response during differential fear conditioning and excitability changes are linked to distinct functional cortical connectivity signatures and resilient outcome. Both, in mice and humans, B5 will conduct state-of-the-art functional connectivity measures, and a back-translation of human stimulus activation paradigms to the mouse. Finally, causal optogenetic manipulations will be developed.

Publications

Muthuraman M, Deuschl G, Koirala N, Riedel C, Volkmann J, Groppa S (2017) Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex. Sci Rep 7:43571.

>> Link to PubMed

Alexandru H, Muthuraman M, Chirumamilla VC, Koirala N, Paktas B, Deuschl G, Zeuner KE, Groppa S (2016) Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy. PLoS One 11(12):e0168652.

>> Link to PubMed

Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Van Diest I, van Harmelen A-L, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017) The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1:784-90.

>> Link to PubMed