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Project B05: Regulation of neural excitability and neural-network function in resilience – a multimodal and (back-) translational approach

Principal Investigators

Prof. Dr. Sergiu Groppa

Professor, Chair of Section of Movement Disorders and Neurostimulation, Consultant of the Clinic of Neurology

Prof. Dr. Albrecht Stroh

Head of Research Group “Molecular Imaging and Optogenetics” at the Institute of Pathophysiology

Head of the “Mainz Animal Imaging Center (MAIC)” and Group Leader at LIR


Prof. Dr. Johannes Vogt

Principal Investigator

Project Team

Our Research

Using neuronavigated transcranial magnetic stimulation over human dorsomedial prefrontal cortex (as a probe) in combination with simultaneous EEG (as a read-out), B05 will determine the excitability and cortico-cortical functional connectivity of this cortex area, pursuing the hypothesis that adaptive stress response during differential fear conditioning and excitability changes are linked to distinct functional cortical connectivity signatures and resilient outcome. Both, in mice and humans, B5 will conduct state-of-the-art functional connectivity measures, and a back-translation of human stimulus activation paradigms to the mouse. Finally, causal optogenetic manipulations will be developed.

Publications

Chiosa V, Ciolac D, Groppa S, Koirala N, Pintea B, Vataman A, Winter Y, Gonzalez-Escamilla G, Muthuraman M, Groppa S (2019) Large-scale network architecture and associated structural cortico-subcortical abnormalities in patients with sleep/awake-related seizures. Sleep 42(4):zsz006. doi: 10.1093/sleep/zsz006

>> Link to PubMed

Chirumamilla VC, Gonzalez-Escamilla G, Koirala N, Bonertz T, von Grothus S, Muthuraman M, Groppa S (2019) Cortical excitability dynamics during fear processing. Front Neuosci 13:568. doi: 10.3389/fnins.2019.00568

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Pflug A, Gompf F, Muthuraman M, Groppa S, Kell CA (2019) Differential contributions of the two human cerebral hemispheres to action timing. eLife 8: 10.7554/eLife.4804

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Gonzalez-Escamilla G, Chirumamilla VC, Meyer B, Bonertz T, von Grotthus S, Vogt J, Stroh A, Horstmann J-P, Tüscher O, Kalisch R, Muthuraman M, Groppa S (2018) Excitability regulation in the dorsomedial prefrontal cortex during sustained instructed fear responses: a TMS-EEG study. Sci Rep 8(1):14506. doi: 10.1038/s41598-018-32781-9

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Muthuraman M, Raethjen J, Koirala N, Anwar AR, Mideksa KG, Elble R, Groppa S, Deuschl G (2018) Cerebello-cortical network fingerprints differ between essential, Parkinson’s and mimicked tremors. Brain 141(6):1770–1781.

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Tamás G, Chirumamilla VC, Anwar AR, Raethjen J, Deuschl G, Groppa S, Muthuraman M (2018) Primary sensorimotor cortex drives the common cortical network for gamma synchronization in voluntary hand movements. Front Hum Neurosci 12:130. doi: 10.3389/fnhum.2018.00130

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Thalman C, Horta G, Qiao L, Endle H, Tegeder I, Cheng H, Laube G, Sigurdsson T, Hauser MJ, Tenzer S, Distler U, Aoki J, Morris AJ, Geisslinger G, Röper J, Kirischuk S, Luhmann HJ, Radzushkin K, Nitsch R, Vogt J (2018) Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders. Mol Psychiatry 23(8):1699–1710.

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Chiosa V, Groppa SA, Ciolac D, Koirala N, Misina L, Winter Y, Moldovanu M, Muthuraman M, Groppa S (2017) Breakdown of thalamo-cortical connectivity precedes spike generation in focal epilepsies. Brain Connect 7(5):309–320.

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Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Van Diest I, van Harmelen A-L, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017) The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1:784-90.

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Muthuraman M, Deuschl G, Koirala N, Riedel C, Volkmann J, Groppa S (2017) Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex. Sci Rep 7:43571.

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Schwalm M, Schmid F, Wachsmuth L, Fois C, Prouvot P H, Kronfeld A, Backhaus H, Albers F, Faber C, Stroh A (2017) Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves. eLife 6:e27602. doi: 10.7554/eLife.27602

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Alexandru H, Muthuraman M, Chirumamilla VC, Koirala N, Paktas B, Deuschl G, Zeuner KE, Groppa S (2016) Grey matter microstructural integrity alterations in blepharospasm are partially reversed by botulinum neurotoxin therapy. PLoS One 11(12):e0168652. doi: 10.1371/journal.pone.0168652

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