EN DE

Project B04: Lipid signaling by anandamide and the bliss of resilience: genetic models at cellular and neural-network levels

Principal Investigators

Prof. Dr. Beat Lutz

Professor and Director of the Institute of Physiological Chemistry

Prof. Dr. Heiko Luhmann

Professor and director of Institute of Physiology

Project Team

Dr. Zeinab Khastkhodaei, Postdoc
Dr. Ermelinda Lomazzo, Postdoc
Margaryta Tevosian, PhD student
Renata Vaz Pandolfo, PhD student
Dr. Jenq-Wei Yang, Postdoc

Our Research

B04 will investigate the role of anandamide signaling in resilience. Anandamide is an endocannabinoid and ligand of the cannabinoid CB1 receptor, implicated in fear extinction, relief from anxiety and HPA axis down-regulation. It is expected that anandamide signaling at the time of stressor exposure facilitates stress response regulation by its effects on neuronal excitability as well as large-scale network function. B04 will genetically enhance anandamide signaling at precise time points during stressor exposure in selected neurons of the network and investigate its effect on excitability, network function, and resilience.

Publications

Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Van Diest I, van Harmelen A-L, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017) The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1:784-90.

>> Link to PubMed