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Project B03: Fear network interactions underlying resilience to stress

Principal Investigators

Torfi Sigurdsson, Ph.D.

Independent Group Leader

Project Team

Sebastian Betz, PhD student

Our Research

B03 investigates how interactions between the amygdala, hippocampus, prefrontal cortex and nucleus accumbens shape resilience to stress. To this end, we will record neural activity in all four structures simultaneously in mice before, during and after exposure to a chronic stressor. We will examine whether functional connectivity between these structures is associated with resilience to stress-induced impairments of social, cognitive and emotional functioning. Optogenetic manipulations will also be performed to test the causal contribution of these network interactions to resilient behavior.