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Project B03: Fear network interactions underlying resilience to stress

Principal Investigators

Torfi Sigurdsson, Ph.D.

Independent Group Leader

Project Team

Our Research

B03 investigates how interactions between the amygdala, hippocampus, prefrontal cortex and nucleus accumbens shape resilience to stress. To this end, we will record neural activity in all four structures simultaneously in mice before, during and after exposure to a chronic stressor. We will examine whether functional connectivity between these structures is associated with resilience to stress-induced impairments of social, cognitive and emotional functioning. Optogenetic manipulations will also be performed to test the causal contribution of these network interactions to resilient behavior.

Publications

Babl SS, Rummell BP, Sigurdsson T (2019) The Spatial Extent of  Optogenetic Silencing in Transgenic Mice Expressing Channelrhodopsin in  Inhibitory Interneurons. Cell Rep 29(5):1381-1395.e4. doi: 10.1016/j.celrep.2019.09.049.

>> Link to PubMed

Salinas-Hernández XI, Vogel P, Betz S, Kalisch R, Sigurdsson T, Duvarci S  (2018) Dopamine neurons drive fear extinction learning by signaling  the omission of expected aversive outcomes. eLife pii: e38818. doi: 10.7554/eLife.38818.

>> Link to PubMed