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Project A05: Deciphering the epigenetic basis of resilience

Principal Investigators

Dr. Jennifer Winter

Group leader

Jun.-Prof. Dr. Susanne Gerber

Principal Investigator

Project Team

Tamer Butto, PhD student
Monika Chongtham, PhD student
Dr. Matthias Linke, Postdoc
Kanak Mungikar, PhD student

Our Research

A05 will exploit natural inter-individual variability of resilience by comparing transcriptomes and genome-wide chromatin accessibility of hippocampus, nucleus accumbens and prefrontal cortex between resilient and non-resilient mice. Next, we will apply specific inhibitors of distinct epigenetic regulators to different groups of mice at the time of stress and compare their later behavioral outcomes with non-drug treated control groups subjected to identical stress. For mice treated with the inhibitor that showed the strongest resilience-promoting effects, we will then determine transcriptomes, genome-wide chromatin accessibility and associated epigenetic marks of the above mentioned brain regions.