Project A05: Deciphering the epigenetic basis of resilience

Principal Investigators

Jun.-Prof. Dr. Susanne Gerber

Junior Professor

Dr. Jennifer Winter

Group Leader

Project Team

Tamer Butto, PhD student
Monika Chongtham, PhD student
Dr. Matthias Linke, Postdoc
Kanak Mungikar, PhD student

Our Research

A05 will exploit natural inter-individual variability of resilience by comparing transcriptomes and genome-wide chromatin accessibility of hippocampus, nucleus accumbens and prefrontal cortex between resilient and non-resilient mice. Next, we will apply specific inhibitors of distinct epigenetic regulators to different groups of mice at the time of stress and compare their later behavioral outcomes with non-drug treated control groups subjected to identical stress. For mice treated with the inhibitor that showed the strongest resilience-promoting effects, we will then determine transcriptomes, genome-wide chromatin accessibility and associated epigenetic marks of the above mentioned brain regions.