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Project A04: Developing a zebrafish model to identify novel mediators of resilience mechanisms

Principal Investigators

Prof. Soojin Ryu, Ph.D.

Professor of Developmental Neurobiology of Resilience

Prof. Erin Margaret Schuman, Ph.D.

Director of Max Planck Institute for Brain Research

Project Team

Our Research

A04 will exploit the short generation times, space-saving housing and excellent genetic manipulability afforded by zebrafish. They develop the first zebrafish model of resilience to chronic stress, which will serve to discover new molecular candidates. Further, A04 applies BONCAT and FUNCAT techniques that allow for identifying newly synthesized (stressor-induced) synaptic proteins in a regionally specific manner. Also, they will use the model to validate discovered candidates by a battery of loss-of-function and gain-of-function approaches that are already well established in zebrafish.

Publications

Castillo-Ramirez LA, Ryu S, De Marc RJ (2019) Active behaviour during early development shapes glucocorticoid reactivity. Sci Rep 9(1):12796. doi: 10.1038/s41598-019-49388-3

>> Link to PubMed

Langebeck-Jensen K, Shahar OD, Schuman EM, Langer JD, Ryu S (2019) Larval zebrafish proteome regulation in response to an environmental challenge. Proteomics 19(4):e1900028. doi: 10.1002/pmic.201900028

>> Link to PubMed

Herzog DP, Beckmann H, Lieb K, Ryu S, Müller MB (2018) Understanding and predicting antidepressant response: Using animal models to move toward precision psychiatry. Front Psychiatry 9:512. doi: 10.3389/fpsyt.2018.00512

>> Link to PubMed