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Project A03: Neuronal actin dynamics shaping resilience: the role of the novel actin-interacting protein ‘downregulated in renal cancer’ (DRR1)

Principal Investigators

Prof. Dr. Marianne Müller

Professor

Prof. Dr. Amparo Acker-Palmer

Project Team

Dr. David Herzog, MD/PhD student
Tanja Jene, PhD student
Dr. Michael van der Kooij, Postdoc
Marta Segarra, PhD student
Olga Tschesnokowa, PhD student

Our Research

A03 investigates the function of the protein DRR1, whose stressor-induced DRR1 up-regulation is a candidate active neural resilience mechanism. A01 proposes that DRR1 regulates the actin-dependent insertion of AMPA receptors at the synapse. Hippocampal AMPA receptor function in turn affects resilience, suggesting a link from stressor-induced changes in the transcriptome via regulation of neural excitability in the hippocampus to resilience. The authors will further apply hypothesis-free approaches serving to discover further molecular candidates, including RNA sequencing of DRR1 overexpressing mice after stress exposure.

Publications

Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Van Diest I, van Harmelen A-L, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017) The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1:784-90.

>> Link to PubMed