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Project A02: Unraveling the relation between adult-born hippocampal neurons’ connectivity and resilience

Principal Investigators

Prof. Dr. Benedikt Berninger

Professor

Prof. Dr. Beat Lutz

Professor and Director of the Institute of Physiological Chemistry

Project Team

Annika Beer, PhD student
Dr. Jéronimo Jurado-Arjona, Postdoc
Nesrin Sharif, PhD student

Our Research

Elevated levels of adult neurogenesis have been proposed as a resilience-conducive trait that protects against stress-related dysfunction by facilitating discrimination during and/or after stressor exposure, the latter being supposed to represent an active resilience mechanism. In A02, we aim at revealing the dependence of resilience to stress-related dysfunction on the degree of circuit integration of adult-born dentate granule cells (DGCs) as determined by rabies virus-based tracing of monosynaptic input connections. We will correlate circuit integration of DGCs and resilience to chronic social defeat stress and search for activity- and neuro-trophin-induced manipulations that improve resilience outcome as a consequence of altered connectivity.

Publications

McAvoy KM, Scobie KN, Berger S, Russo C, Guo N, Decharatanachart P, Vega-Ramirez H, Miake-Lye S, Whalen M, Nelson M, Bergami M, Bartsch D, Hen R, Berninger B, Sahay A (2016) Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits. Neuron 91(6):1356-73.

>> Link to PubMed

Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Van Diest I, van Harmelen A-L, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017) The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav 1:784-90.

>> Link to PubMed