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Prof. Dr.
Jochen Roeper

Professor of Neurophysiology and Director of Center of Physiology, Goethe University Frankfurt

Contact

Institute for Neurophysiology
Goethe University Frankfurt/Main
Theodor-Stern-Kai 7
60596 Frankfurt/Main

+49 (0) 69 6301 84091/92

CRC 1193 PROJECTS

Expertise

Electrophysiology

My research interest is to understand the role of defined ion channels in generating behaviorally relevant patterns of electrical activity in subtypes of dopamine midbrain neurons under physiological conditions and in mouse models of Parkinson disease, Schizophrenia and resilience. We combine single cell neurophysiology in vivo and in vitro with retrograde and juxtacellular labeling as well as targeted expression of mutant channel constructs and transgenic mice.

Vita

Since 2008

Director, Center of Physiology, Goethe University Frankfurt

Since 04/2007

Director (W3), Full Professor (tenure), Institute of Neurophysiology, Goethe University Frankfurt

04/2002 – 04/2007

Associate Professor (C3, tenure), Department of Physiology, University of Marburg

04/1999 – 04/2002

Assistant Professor (tenure-track), MRC Anatomical Neuropharmacology Unit, University of Oxford, UK

04/1994 – 04/1999

Research Scientist, Center for Molecular Neurobiology (ZMNH), University of Hamburg 

04/1992 – 04/1994

Postdoctoral Fellow, Dept.of Physiology, University of Oxford, UK

11/1986 – 03/1992

Graduate Student, Institute of Physiology, University of Hamburg

Publications

Krabbe S, Duda J, Schiemann J, Poetschke C, Schneider G, Kandel ER, Liss B, Roeper J, Simpson EH. (2015) Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area. Proc Natl Acad Sci USA 112:E1498-506.

>> Link to PubMed

Subramaniam M, Althof D, Gispert S, Schwenk J, Auburger G, Kulik A, Fakler B, Roeper J. (2014) Mutant α-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channels. J Neurosci 34:13586-99.

>> Link to PubMed

Schiemann J, Schlaudraff F, Klose V, Bingmer M, Seino S, Magill PJ, Zaghloul KA, Schneider G, Liss B, Roeper J. (2012) K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration. Nature Neurosci 15:1272-80.

>> Link to PubMed

Lammel S, Hetzel A, Häckel O, Jones I, Liss B, Roeper J. (2008) Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. Neuron 57:760-73.

>> Link to PubMed

Liss B, Haeckel O, Wildmann J, Miki T, Seino S and Roeper J (2005) KATP channels promote differential degeneration of dopaminergic midbrain neurons. Nature Neurosci 8:1742-51.

>> Link to PubMed

Coordinating Functions

2017

Speaker, Excellence Cluster Initiative “youngsbrains@risk”

2016

Speaker, Rhine-Main-Neuroscience Network

2016

Steering Committee CRC 1193

2013

Steering Committee CRC 1080

Editorial and Scientific Advisory Board

2015

Section Editor “European Journal of Neuroscience”

2013

Reviewing Editor “The Journal of Physiology”

2004 – 2010

Council Member of International Basal Ganglia Society

Awards, Grants and Honor

2015

Gutenberg research fellowship, Mainz University

2013

Prize for excellent teaching, Goethe University

2004

Prize for excellent teaching, Marburg University

2001

Exhibitor, Royal Society UK

1999

Senior Fellowship, Exeter College Oxford

1992

Postdoctoral Fellowship, DFG

1991

Prize Fellowship, Magdalen College Oxford

1991

Fellowship, Parkinson Disease Society

1985

Scholarship, National Scholarship Foundation Germany