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Konstantin Radyushkin, Ph.D.

Head of Mouse Behavior Outcome Unit

Contact

Mouse Behavior Outcome Unit
Focus Program Translational Neurosciences (FTN)
Johannes Gutenberg-University Mainz
Hanns-Dieter-Hüsch-Weg 19
55128 Mainz

+49 (0) 6131 39 21333

CRC 1193 PROJECTS

Expertise

Animal Behavior

Translational neuroscience; development of mouse models for neural and psychiatry diseases (with focus on autism and schizophrenia) in order to study genetic and environmental factors of pathogenesis and to develop novel treatment approaches.

Vita

Since 08/2011

Head of Mouse Behavior Outcome Unit, Focus Program Translational Neurosciences (FTN), Johannes Gutenberg University, Mainz

2005 – 2011

Staff scientist at the Division of Clinical Neuroscience, Max Planck Institute for Experimental Medicine, Göttingen

2000 – 2005

Post-doctoral position at the Department Molecular Cell Biology, Max Planck Institute for biophysical Chemistry, Göttingen

1988 – 1999

Post-doctoral position at the Department of Systemogenesis, Anokhin institute of normal physiology, Russian Academy of Medical Science, Moscow, Russia

Publications

Cheng J, Sahani S, Hausrat TJ, Yang JW, Ji H, Schmarowski N, Endle H, Liu X, Li Y, Böttche R, Radyushkin K, Maric HM, Hoerder-Suabedissen A, Molnár Z, Prouvot PH, Trimbuch T, Ninnemann O, Huai J, Fan W, Visentin B, Sabbadini R, Strømgaard K, Stroh A, Luhmann HJ, Kneussel M, Nitsch R, Vogt J (2016) Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling. Neuron 92(1):126-142.

>> Link to PubMed

Shahmoradi A, Radyushkin K, Rossner MJ (2015) Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex. Proc Natl Acad Sci USA 112(27):E3582-9.

>> Link to PubMed

Agarwal A, Zhang M, Trembak-Duff I, Unterbarnscheidt T, Radyushkin K, Dibaj P, Martins de Souza D, Boretius S, Brzózka MM, Steffens H, Berning S, Teng Z, Gummert MN, Tantra M, Guest PC, Willig KI, Frahm J, Hell SW, Bahn S, Rossner MJ, Nave KA, Ehrenreich H, Zhang W, Schwab MH (2014) Dysregulated expression of neuregulin-1 by cortical pyramidal neurons disrupts synaptic plasticity. Cell Rep 8(4):1130-45.

>> Link to PubMed

Radyushkin K, El-Kordi A, Boretius S, Castaneda S, Ronnenberg A, Reim K, Bickeböller H, Frahm J, Brose N, Ehrenreich H (2010) Complexin2 null mutation requires a 'second hit' for induction of phenotypic changes relevant to schizophrenia. Genes Brain Behav 9(6):592-602.

>> Link to PubMed

Jamain S, Radyushkin K, Hammerschmidt K, Granon S, Boretius S, Varoqueaux F, Ramanantsoa N, Gallego J, Ronnenberg A, Winter D, Frahm J, Fischer J, Bourgeron T, Ehrenreich H, Brose N (2008) Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. Proc Natl Acad Sci USA 105(5):1710-5.

>> Link to PubMed