B03 investigates how interactions between the amygdala, hippocampus, prefrontal cortex and nucleus accumbens shape resilience to stress. To this end, we will record neural activity in all four structures simultaneously in mice before, during and after exposure to a chronic stressor. We will examine whether functional connectivity between these structures is associated with resilience to stress-induced impairments of social, cognitive and emotional functioning. Optogenetic manipulations will also be performed to test the causal contribution of these network interactions to resilient behavior.
Babl SS, Rummell BP, Sigurdsson T (2019) The Spatial Extent of Optogenetic Silencing in Transgenic Mice Expressing Channelrhodopsin in Inhibitory Interneurons. Cell Rep 29(5):1381-1395.e4. doi: 10.1016/j.celrep.2019.09.049.
Salinas-Hernández XI, Vogel P, Betz S, Kalisch R, Sigurdsson T, Duvarci S (2018) Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes. eLife pii: e38818. doi: 10.7554/eLife.38818.