Soojin Ryu, Ph.D.

Professor of Developmental Neurobiology of Resilience


German Resilience Center
University Medical Center Johannes Gutenberg University Mainz
Duesbergweg 6
55128 Mainz

+49 (0) 6131 39 29111



Using zebrafish to decipher mechanisms underlying 1) stress resilience/vulnerability and 2) regulation of acute stress reactions


Since 6/2015

W2 Professor of Developmental Neurobiology of Resilience, University Medical Center of the Johannes Gutenberg University

2008 – 2015

Max Planck Research Group Leader, Max Planck Institute for Medical Research, Heidelberg

2000 – 2007

Postdoctoral researcher, Department of Developmental Biology, University of Freiburg

1994 – 1999

Doctoral student, Department of Molecular and Cell Biology, University of California, Berkeley


De Marco RJ, Thiemann T, Groneberg AH, Ryu S (2016) Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behavior. Nat Commun 7:12620.

>> Link to PubMed

Vom Berg-Maurer CM, Trivedi CA, Bollmann JH, De Marco RJ, Ryu S (2016) The severity of acute stress is represented by increased synchronous activity and recruitment of hypothalamic neurons. J Neurosci 36:3350-62.

>> Link to PubMed

Wolf A, Ryu S (2013) Specification of posterior hypothalamic neurons requires coordinated activities of Fezf2, Otp, Sim1a and Foxb1.2. Development 140:1762-73.

>> Link to PubMed

Ryu S, Mahler J, Acampora D, Holzschuh J, Erhardt S, Simeone A, Driever W (2007) Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development. Curr Biol 17:873-80.

>> Link to PubMed

Ryu S, Zhou S, Laudurner AG, Tjian R (1999) Transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Nature 397:446-50.

>> Link to PubMed

Coordinating Functions

Since 2014

Steering committee member, DFG Priority Programme „Next Generation Optogenetics: Tool Development and Application“ (SPP 1926)

2012 – 2015

Steering committee member, Interdisciplinary Center for Neuroscience, University of Heidelberg


Second phase preparation committee member, Excellence Cluster CellNetworks, University of Heidelberg

Awards, Grants and Honor

2016 – 2019

DFG-Schwerpunkt 1926 „Next Generation Optiogenetics“

2015 – 2020

BMBF- Selbständige Froschungsgruppen in den Neurowissenschaften Grant

2010 – 2016

DFG-Forschergruppe 1279 “Protein based photoswitches” Grant Member

2013 – 2016

University of Heidelberg Excellence Initiative EcTOP Program Grant

2010 – 2013

EU FP7 PEOPLE “Neuroendocrine Influence on Aging” Grant

2010 – 2013

University of Heidelberg Frontiers Innovation Grant

2009 – 2012

Behrens-Weise Foundation Research Grant

2000 – 2003

Human Frontiers Science Program Postdoctoral Fellowship


Alexander von Humboldt Foundation Postdoctoral Fellowship

1996 – 1999

Howard Hughes Medical Institute Predoctoral Fellowship


2012 – 2015

General assembly member, Excellence Cluster CellNetworks, University of Heidelberg