Prof. Dr.
Beat Lutz

Professor and Director of the Institute of Physiological Chemistry

Scientific Director and Group Leader at LIR


Institute of Physiological Chemistry
University Medical Center of the Johannes Gutenberg University
Leibniz Institute for Resilience Research (LIR) gGmbH

Duesbergweg 6 | Wallstraße 7 (LIR)
55128 | 55122 (LIR) Mainz

+49 (0) 6131 39 25912



Behavioral Genetics. 

Mechanisms underlying learning and memory. 

Epigenetic mechanisms underlying behavior. 

Lipid signaling systems (mainly on endocannabinoids and cannabinoid receptors) in the brain and peripheral organs. 

Roles of endocannabinoid system in anxiety, fear memory, stress coping, synaptic plasticity, neurogenesis, neural development, and energy metabolism.


Since 01/2020

Scientific Director and Research Group Leader of Leibniz Institute of Resilience Research (LIR) gGmbH, Mainz

01/2018 – 12/2019

Scientific Director of German Resilience Center (DRZ) gGmbH, Mainz

Since 01/2009

Director fo the Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz

Since 10/2004

W3 Professor for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz

04/1997 – 09/2004

Independent Group Leader of the Max Planck Society at the Max Planck Institute of Psychiatry (Munich)

04/1995 – 03/1997

Senior Scientist at the DKFZ (Heidelberg)

04/1989 – 03/1995

Postdoctoral positions at ETH (Zurich), Harvard Medical School (Boston), and Baylor College of Medicine (Houston)


Lutz B, Marsicano G, Maldonado R, Hillard CJ (2015) The endocannabinoid system in gating fear, anxiety and stress. Nat Rev Neurosci 16:705-18.

>> Link to PubMed

Lomazzo E, Bindila L, Remmers F, Lerner R, Schwitter C, Hoheisel U, Lutz B (2015) Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain. Neuropsychopharmacol 40:488-501.

>> Link to PubMed

Ruehle S, Remmers F, Romo-Parra H, Massa F, Wickert M, Wörtge S, Häring M, Kaiser N, Marsicano G, Pape HC, Lutz B (2013) Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions. J Neurosci 33:10264-77.

>> Link to PubMed

Rey AA, Purrio M, Viveros MP, Lutz B (2012) Biphasic effects of cannabinoids in anxiety responses: CB1 and GABAB receptors in the balance of GABAergic and glutamatergic neurotransmission. Neuropsychopharmacol 37:2624–34.

>> Link to PubMed

Marsicano G, Wotjak CW, Azad SC, Bisogno T, Rammes G, Song T, Hofmann C, Zieglgänsberger W, Di Marzo V, Lutz B (2002) The endogenous cannabinoid system controls extinction of aversive memories. Nature 418:530-5.

>> Link to PubMed

Coordinating Functions

Since 01/2020

Scientific Director of the Leibniz Institute for Resilience Research (LIR), Mainz

Since 08/2016

Scientific Director of the German Resilience Center (DRZ), Mainz

Since 06/2016

Spokesperson of CRC 1193 “Neurobiology of Resilience”

Since 2015

Co-organizer (with R. Kalisch, Mainz): “International Symposium on Resilience Research”, Mainz

Since 2009

Member of the Fachbereichsrat, University Medical Center, Mainz

2008 - 2014

Chairperson of DFG Research Unit FOR926 (with A. Zimmer, Bonn)


Organizer Symposium at FENS Meeting: “Ramping up resilience”


Chair of Gordon Research Conference “Cannabinoid Functions in the CNS”


Organizer Symposium at FENS Meeting: “Endocannabinoids in the developing brain”

Editorial and Scientific Advisory Board

Since 2014

Member of the Board of Directors of German Resilience Center (DRZ), Mainz

Awards, Grants and Honor


Ester Fride Awad for Major Contributions to Cannabinoid Research


Mechoulam Award for Outstanding Contributions to Cannabinoid Research

2003 - 2004

Stipend from the Hertie-Foundation (Excellence Program in Neurosciences)


Organon Prize for Psychiatry

1990 - 1994

Fellowships from the Swiss National Foundation


Since 10/2015

Member of Academia Europaea

Since 1998

Society of Neuroscience

Since 1998

International Cannabinoid Research Society