Prof. Dr.
Klaus Lieb

Professor and Director of Department of Psychiatry and Psychotherapy


Department of Psychiatry and Psychotherapy
University Medical Center Johannes Gutenberg-University Mainz
Untere Zahlbacher Str. 8
55131 Mainz

+49 (0) 6131 17 7335




Neurobiology and therapy of affective disorders and personality disorders; cognitive enhancement; resilience against mental disorders; conflicts of interest in medicine


Since 01/2020

Scientific Managing Director and Research Group Leader at Leibniz Institute for Resilience Research (LIR) gGmbH, Mainz

01/2018 – 12/2019

Scientific Managing Director at German Resilience Center (DRZ) gGmbH, Mainz

Since 04/2007

Professor for Psychiatry and Psychotherapy (W3) and director Department of Psychiatry and Psychotherapy, Johannes Gutenberg University Medical Center Mainz

06/2001 – 03/2007

Chief Physician and Vice Chairman at the Department of Psychiatry and Psychotherapy of the University Medical Center Freiburg

02/1999 – 05/2001

Consultant psychiatrist and group leader, University Medical Center Freiburg

09/1994 – 02/1999

Research assistant/Junior doctor at the Psychiatric University Hospital, Freiburg

09/1994 – 08/1995

Postdoctoral fellow of the German Research Foundation (DFG) in the Neurobiology Laboratory of the University Hospital for Psychiatry, Freiburg

10/1992 – 09/1994

Postdoctoral fellow, Department of Anatomy and Cell Biology and Internal Medicine, University of Ulm, Germany


Lieb K, Dreimüller N, Wagner S, Schlicht K, Falter T, Neyazi A, Müller-Engling L, Bleich S, Tadić A, Frieling H. (2018) BDNF plasma levels and BDNF exon IV promoter methylation as predictors for antidepressant treatment response. Front Psychiatry 9:511. doi: 10.3389/fpsyt.2018.00511

>> Link to PubMed

Chmitorz A, Kunzler A, Helmreich I, Tüscher O, Kalisch R, Kubiak T, Wessa M, Lieb K (2018) Intervention studies to foster resilience - A systematic review and proposal for a resilience framework in future intervention studies. Clin Psychol Rev 59:78–100.

>> Link to PubMed

Franke AG, Gränsmark P, Agricola A, Schühle K, Rommel T, Sebastian A, Balló HE, Gorbulev S, Gerdes C, Frank B, Ruckes C, Tüscher O, Lieb K (2017) Methylphenidate, modafinil, and caffeine for cognitive enhancement in chess: A double-blind, randomised controlled trial. Eur Neuropsychopharmacol 27(3):248-260.

>> Link to PubMed

Tadic A, Müller-Engling L, Schlicht KF, Kotsiari A, Dreimüller N, Kleimann A, Bleich S, Lieb K, Frieling H: (2014) Methylation of the promotor of brain-derived neurotrophic factor exon IV and antidepressant response in major depression. Mol Psychiatry 19:281-3.

>> Link to PubMed

Lieb K, Völlm B, Rücker G, Timmer A, Stoffers JM (2010) Pharmacotherapy for Borderline Personality Disorder. Cochrane systematic review of randomised trials. Br J Psychiatry 196:4-12

>> Link to PubMed

Lieb K, Zanarini MC, Schmahl C, Linehan MM, Bohus M (2004) Borderline personality disorder. Lancet 364:453-61.

>> Link to PubMed

Lieb K, Brucker S, Bach M, Els T, Lücking CH, Greenlee MW (1999) Impairment in preattentive visual processing in patients with Parkinson`s disease. Brain 122:303-13.

>> Link to PubMed

Coordinating Functions

Since 7/2014

Co-Director at the German Resilience Center (Deutsches Resilienz Zentrum) Mainz

Since 2014

Co-speaker of the German Resilience Center Mainz

Mentoring Functions

Editorial and Scientific Advisory Board

Since 2009

Editor Cochrane Library of systematic reviews (section personality disorders)

Awards, Grants and Honor


Hochschullehrer des Jahres (Deutscher Hochschulverband)


Hamburger Preis Persönlichkeitsstörungen


Golden Helix Award


Hormosan-Forschungspreis Psychiatrie


Stipend of DFG, University of Freiburg


Since 2009

Official member of the scientific commission psychotherapy of the German Medical Association

Since 2009

Official member of the Drug Commission of the German Medical Association